Each soft capsule contains: Active ingredient: Vitamin E 400IU.
Excipients/Inactive Ingredients: soybean oil, gelatin, glycerin, ethyl vanillin, methyl paraben, propyl paraben.
The exact biological function of vitamin E in humans is unknown, although the vitamin is believed to act as an antioxidant. It has been postulated that vitamin E protects cellular membranes and other oxygen-sensitive substances such as vitamin A and ascorbic acid (vitamin C) from oxidation. Coenzyme Q, selenium, synthetic antioxidants, and some sulfur-containing amino acids can prevent vitamin E deficiency syndromes in animals. Most, but not all, studies have found that vitamin E decreases platelet aggregation. Vitamin E deficiency does not cause specific disease in adults; in premature neonates, irritability, edema, thrombosis and hemolytic anemia may be caused by vitamin E deficiency. Creatinuria, ceroid deposition, muscle weakness, decreased erythrocyte survival or increased in vitro hemolysis by oxidizing agents has been identified in adults and children with low serum tocopherol concentrations. Administration of vitamin E completely reverses the signs of vitamin E deficiency.
Vitamin E is used in the treatment and prevention of vitamin E deficiency (inadequate dietary intake, children with cystic fibrosis or biliary atresia malabsorption of fat, or abetalipoproteinaemia, premature very low birth weight infants).
Vitamin E is also used often as an antioxidant in pharmaceutical manufacturing.
Adults: One soft capsule daily.
Pregnant women: pregnant women who have a good nutrition should not take vitamin E supplements as amount of vitamin E in diet is adequate.
In individuals with malnutrition, vitamin E supplements should be taken as daily sufficient need and under the doctor's prescription.
Cystic fibrosis: 100 - 200mg of dl-alphatocopheryl acetate or about 67 - 135mg of d-alphatocopherol.
A betalipoproteinaemia: 50 - 100mg of dl-alphatocopheryl acetate per kg body weight or about 33 - 67mg of d-alphatocopherol per kg.
Hypersensitivity to any component of the product.
Vitamin E may increase the effects of anticoagulants and warfarins.
Vitamin E may potentiate the action of aspirin to inhibit on platelet aggregation.
Pregnancy: Pregnant women who have a good nutrition should not take vitamin E supplements as amount of vitamin E in diet is adequate. In individuals with malnutrition, vitamin E supplements should be taken as daily sufficient need.
Lactation: vitamin E passes into milk, vitamin E level in human milk is higher 5 times than in cow milk and human milk is more effective in maintaining serum sufficient vitamin E level for children until 1 year old.
Daily vitamin E need in lactation is 12mg. Breast-feeding mothers should only take vitamin E supplements when vitamin E quantity in diet is not supplied sufficiently as daily need.
Vitamin E is usually well tolerated. Large doses of Vitamin E may occur diarrhea, abdominal pain, other gastro-intestinal disturbances, and have also been reported to cause fatigue and weakness.
Inform the doctor or pharmacist in case of any adverse reactions related to drug use.
Vitamin E increases the absorption, intake and storage of vitamin A, and may protect against the vitamin A redundancy disease, however, these effects have been still discussed upon.
The use of vitamin E dosages greater than 10IU/kg of body weight may slow response to the treatment therapy with iron in children suffering from iron-deficiency anemia and may result in hemolytic anemia due to vitamin E deficiency in children treated with iron supplements. Vitamin E and its metabolites may protect against the action of vitamin K. Patients who take oral anticoagulants have risk of hemorrhage after taking the large dose of vitamin E. In healthy volunteers, vitamin E did not change clotted blood process.
The excessive use of mineral oil may decrease the vitamin E absorption.
In well-closed container, dry and cool place, below 30°C.
Shelf Life: 36 months from the manufacturing date.
A11HA03 - tocopherol (vit E) ; Belongs to the class of other plain vitamin preparations. Used as dietary supplements.
Soft cap 400 IU x 3 x 10's.
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